Natural Product Synthesis

Natural Product Synthesis – Chemical Discovery through the Pursuit of Complex Molecular Scaffolds

The general research paradigm within the Stoltz laboratory is to utilize architecturally complex target molecules as the driving force behind the development of new reactions. Naturally, these endeavors continuously push the boundaries of known chemical reactivity, highlighting the limitations of current technologies. The ensuing synthetic effort represents not only a feat of synthetic strategy, but one of creativity and ingenuity.

Check out these recently completed projects:

(–)-Hunterine A – J. Am. Chem. Soc. 2024

Aleutianamine - J. Am. Chem. Soc. 2023

Strempeliopidine – J. Am. Chem. Soc. 2023

(–)-Yonarolide – Chem. Sci. 2023

(+)–Ineleganolide – J. Am. Chem. Soc. 2023

Havellockate – J. Am. Chem. Soc. 2022

Eburnamonine, Eucophylline, and 16′-epi-Leucophyllidine – Angew. Chem. Int. Ed. 2021

(–)-Scabrolide A – J. Am. Chem. Soc. 2020

(–)-Myrifabral A and B – Chem. Sci. 2020

15-Deoxy–Δ(12,14)-Prostaglandin-J2 – Org. Lett. 2019

(–)-jorunnamycin A and (–)-jorumycin – Science 2019

Δ(12)-Prostaglandin J Natural Products – J. Am. Chem. Soc. 2019

(–)-Platencin – Synthesis 2018 [Dedicated to Prof. Dr. Scott E. Denmark on the occasion of his 65th birthday.]

Stephadiamine (with Prof. Dirk Trauner) – J. Am. Chem. Soc. 2018

Below are examples of molecules previously synthesized by our group: