The Stoltz Group

Natural Product Synthesis and Synthetic Methodology

California Institute of Technology • Pasadena, California

The Stoltz Group - Research Interests

Synthesis and Methodology Chart

Research in our group has been initiated in the general area of chemical synthesis with a focus on the development of new strategies for the preparation of complex molecules possessing interesting structural, biological, and physical properties. In concert with the design and development of unique and efficient synthetic strategies, we will develop new techniques and methods which will be useful in far reaching and unanticipated applications, as well as for the synthesis of the initial inspirational target. Thus, the general research paradigm within the Stoltz laboratory will be to utilize architecturally complex target molecules as the driving force behind the development of new reactions, which extend the limits of the science. Ultimately, we will have access to important biologically active compounds prepared through novel and efficient routes, as well as new techniques for the preparation of other structurally unique targets.

Click to enlarge images...

Palladium-Catalyzed Asymmetric Conjugate Addition

Palladium-Catalyzed Asymmetric Conjugate Addition

Atmospheric Oxidation of Isoprene

Palladium(II)-Catalyzed Oxidative Kinetic Resolution

Palladium (II)-Catalyzed Oxidative Cyclizations


A Diastereodivergent Synthetic Strategy for the Syntheses of Communesin F and Perophoramidine

Utilizing the Unique Reactivity of Arynes in Synthesis

Tandem Wolff-Cope Rearrangement

Dragmacidin F