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The Total Synthesis of Quinine
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"The Total Synthesis of Quinine"
R. B. Woodward and W. E. Doering
J. Am. Chem. Soc. 1945, 67, 860-875. DOI Link
Handout: Download PDF
Presented by Chris Gilmore.
08 Feb 2008 |
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Asteriscanolide and Pleocarpenone
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"Intramolecular Cyclobutadiene Cycloaddition/Cyclopropanation/Thermal Rearrangement: An Effective Strategy for the Asymmetric Syntheses of Pleocarpenene and Pleocarpenone"
Michael J. Williams, Holly L. Deak, and Marc L. Snapper
J. Am. Chem. Soc. 2007, 129, 486-487. DOI Link
"Sequential Intramolecular Cyclobutadiene Cycloaddition, Ring-Opening Metathesis, and Cope Rearrangement: Total Syntheses of (+)- and (-)-Asteriscanolide"
John Limanto and Marc L. Snapper
J. Am. Chem. Soc. 2000, 122, 8071-8072. DOI Link
Presented by Pam Tadross.
04 Jan 2008 |
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(+)-Batzelladine A and (–)-Batzelladine D
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"Total Synthesis of (+)-Batzelladine A and (–)-Batzelladine D via [4 + 2]-Annulation of Vinyl Carbodiimides with N-Alkyl Imines"
Michael A. Arnold, Kenneth A. Day, Sergio G. Durón, and David Y. Gin
J. Am. Chem. Soc. 2006, 128, 13255-13260. DOI Link
Presented by Andy McClory.
30 Nov 2007 |
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Proto-Daphniphylline
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"Biomimetic Total Synthesis of Proto-Daphniphylline"
Serge Piettre and Clayton Heathcock
Science 1990, 248, 1532-1534. Document
Presented by Sandy Ma.
12 Oct 2007 |
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Salvinorin A
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" Asymmetric Synthesis of Salvinorin A, A Potent &kappa Opioid Receptor Agonist"
Jonathan R. Scheerer, Jonathan F. Lawrence, Grace C. Wang, and David A. Evans
J. Am. Chem. Soc. 2007, 129, 8968-8969. DOI Link
Presented by Narae Park.
28 Sep 2007 |
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Saxitoxin
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"(+)-Saxitoxin: A First and Second Generation Stereoselective Synthesis"
J. J. Fleming, M. D. McReynolds, and J. Du Bois
J. Am. Chem. Soc. 2007, 129, 9964-9975. DOI Link
Presented by Sam Levine and Krastina Petrova.
14 Sep 2007 |
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Viridin
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"Synthesis of the Furanosteroidal Antibiotic Viridin"
Edward A. Anderson, Erik J. Alexanian, Erik J. Sorensen
Angew. Chem. Int. Ed. 2004; 43, 1998-2001. DOI Link
Presented by Pam Tadross.
31 Aug 2007 |
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(±)-Nominine
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"Efficient Synthetic Access to the Hetisine C20-Diterpenoid Alkaloids. A Concise Synthesis of Nominine via Oxidoisoquinolinium-1,3-Dipolar and Dienamine-Diels-Alder Cycloadditions"
Kevin M. Peese and David Y. Gin
J. Am. Chem. Soc.; 2006; 128(27) pp 8734 - 8735. DOI Link
Handout: Download PDF
Presented by Mike Krout.
17 Aug 2007 |
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(±)-Phalarine
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"Total Synthesis of Phalarine"
Chaomin Li, Collin Chan, Annekatrin C. Heimann, and Samuel J. Danishefsky
Angew. Chem. Int. Ed. 2007; 46(9) pp 1448 - 1450. DOI Link
Presented by Jenn Stockdill.
27 Jul 2007 |
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(±)-Merrilactone A
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"Total Synthesis of (±)-Merrilactone A via Catalytic Nazarov Cyclization"
Wei He, Jie Huang, Xiufeng Sun, and Alison J. Frontier
J. Am. Chem. Soc.; 2007; 129(3) pp 498 -499. DOI Link
Presented by JT Mohr.
13 Jul 2007 |
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Spirotenuipesines A and B
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"The Total Synthesis of Spirotenuipesines A and B"
Mingji Dai and Samuel J. Danishefsky
J. Am. Chem. Soc.; 2007; 129(12) pp 3498 - 3499. DOI Link
Presented by Amanda Jones.
25 May 2007 |
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(+)-GB13 and (+)-Himgaline
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"Total Synthesis of (+)-Galbulimima Alkaloid 13 and (+)-Himgaline"
David A. Evans and Drew J. Adams
J. Am. Chem. Soc.; 2007; 129(5) pp 1048 - 1049. DOI Link
Presented by Brinton Seashore-Ludlow.
11 May 2007 |
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Ring-Expanded Bryostatin Analogue
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"Synthesis of a Ring-Expanded Bryostatin Analogue"
Barry M. Trost, Hanbiao Yang, Oliver R. Thiel, Alison J. Frontier, and Cheyenne S. Brindle
J. Am. Chem. Soc.; 2007; 129(8) pp 2206 - 2207. DOI Link
Presented by John Phillips.
06 Apr 2007 |
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(–)-Alstonerine
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"Concise, Enantioselective Total Synthesis of (–)-Alstonerine"
Kenneth A. Miller and Stephen F. Martin
Org. Lett.; 2007; 9(6) pp 1113 - 1116. DOI Link
Leading Reference
Presented by JT Mohr.
09 Mar 2007 |
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Guanacastepenes A and E
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"Convergent, Enantioselective Syntheses of Guanacastepenes A and E Featuring a Selective Cyclobutane Fragmentation"
William D. Shipe and Erik J. Sorensen
J. Am. Chem. Soc.; 2006; 128(21) pp 7025 - 7035. DOI Link
Leading Reference
Presented by Jennifer Roizen.
09 Feb 2007 |
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11-O-Debenzoyltashironin
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"The Total Synthesis of (±)-11-O-Debenzoyltashironin"
Silas P. Cook, Alessandra Polara, and Samuel J. Danishefsky
J. Am. Chem. Soc.; 2006; 128(51) pp 16440 - 16441. DOI Link
Presented by Charles Liu.
12 Jan 2007 |
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Progress toward Bacchopetiolone
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"Progress toward the Total Synthesis of Bacchopetiolone: Application of a Tandem Aromatic Oxidation/Diels-Alder Reaction"
Amélie Bérubé, Ioana Drutu, and John L. Wood
Org. Lett.; 2006; 8(24) pp 5421 -5424. DOI Link
Presented by Jenn Stockdill.
01 Dec 2006 |
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Antheliolide A
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"Total Synthesis of Antheliolide A"
Chandra Sekhar Mushti, Jae-Hun Kim, and E. J. Corey
J. Am. Chem. Soc.; 2006; 128(43) pp 14050 - 14052. DOI Link
Presented by Pam Tadross.
27 Oct 2006 |
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(+)- and (–)-Nigellamine A2
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"Enantioselective Total Synthesis of (+)- and (–)-Nigellamine A2"
Jianwei Bian, Matthew Van Wingerden,, and Joseph M. Ready
J. Am. Chem. Soc.; 2006; 128(23) pp 7428 - 7429. DOI Link
Presented by Dave Ebner.
29 Sep 2006 |
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Molecule of the "Month": Epi-eriocalyxin A
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Org. Lett.; 2004; 6(23) pp 4327 - 4330. DOI Link
Flyer: Download PDF
Presented by Chris Gilmore and Mike Krout.
04 Aug 2006 |
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(±)-Aspidophytine
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"Application of the Rh(II) Cyclization/Cycloaddition Cascade for the Total Synthesis of (±)-Aspidophytine"
José M. Mejía-Oneto and Albert Padwa
Org. Lett., 8 (15), 3275 -3278. DOI Link
Presented by John Phillips.
07 Jul 2006 |
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(–)-Samaderine Y
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"Total Synthesis of (–)-Samaderine Y from (S)-(+)-Carvone"
Tony K. M. Shing and Ying Y. Yeung
Angew. Chem. Int. Ed. 2006; 44(48) pp 7981 - 7984. DOI Link
Presented by Dan Caspi.
09 Jun 2006 |
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Abyssomicin C
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"Total Synthesis of Abyssomicin C and atrop-Abyssomicin C"
K. C. Nicolaou and Scott T. Harrison
Angew. Chem. Int. Ed. 2006; 45(20) pp 3256 - 3260. DOI Link
Presented by Chris Gilmore.
12 May 2006 |
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(±)-Lepadiformine
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"Total Synthesis of the Marine Alkaloid (±)-Lepadiformine via a Radical Carboazidation"
Pascal Schär and Philippe Renaud
Org. Lett.; 2006; 8(8) pp 1569 - 1571. DOI Link
Presented by Chris Douglas.
14 Apr 2006 |
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11-Desmethyllaulimalide
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"Total Synthesis and Biological Evaluation of 11-Desmethyllaulimalide, a Highly Potent Simplified Laulimalide Analogue"
Paul A. Wender, Michael K. Hilinski, Nicolas Soldermann, and Susan L. Mooberry
Org. Lett.; 2006; 8(7) pp 1507 - 1510. DOI Link
Presented by Ryan McFadden.
17 Mar 2006 |
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(+)-Brasilenyne
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"Intramolecular Silicon-Assisted Cross-Coupling: Total Synthesis of (+)-Brasilenyne"
Scott E. Denmark and Shyh-Ming Yang
J. Am. Chem. Soc.; 2002; 124(51) pp 15196 - 15197. DOI Link
Presented by Charles Liu.
24 Feb 2006 |
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Palominol, Dolabellatrienone, Araneosene, and Isoedunol
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"Concise Total Syntheses of Palominol, Dolabellatrienone, Araneosene, and Isoedunol via an Enantioselective Diels-Alder Macrobicyclization"
Scott A. Snyder and E. J. Corey
J. Am. Chem. Soc.; 2006; 128(3) pp 740 - 742. DOI Link
Presented by Dave Ebner.
20 Jan 2006 |
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ABC Ring of Micrandilactone A
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"Application of RCM Reaction in the Construction of ABC Ring of Micrandilactone A"
Yan-Dong Zhang, Ye-Feng Tang, Tuo-Ping Luo, Juan Shen, Ji-Hua Chen, and Zhen Yang
Org. Lett.; 2006; 8(1) pp 107 - 110. DOI Link
Presented by Ryan McFadden.
16 Dec 2005 |
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Welwitindolinone A and Fischerindoles I and G
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"Enantioselective Total Syntheses of Welwitindolinone A and Fischerindoles I and G"
Phil S. Baran and Jeremy M. Richter
J. Am. Chem. Soc.; 2005; 127(44) pp 15394 - 15396. DOI Link
Presented by Chris Douglas.
11 Nov 2005 |
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(±)-Garsubellin A
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"Total Synthesis of (±)-Garsubellin A"
Akiyoshi Kuramochi, Hiroyuki Usuda, Kenzo Yamatsugu, Motomu Kanai, and Masakatsu Shibasaki
J. Am. Chem. Soc.; 2005; 127(41) pp 14200 - 14201. DOI Link
Presented by Dave Ebner.
21 Oct 2005 |
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Reblastatin
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"Total Synthesis of Reblastatin"
Iwona E. Wrona, Ana E. Gabarda, Gwilherm Evano, and James S. Panek
J. Am. Chem. Soc.; 2005; 127(43) pp 15026 - 15027. DOI Link
Presented by JT Mohr.
14 Oct 2005 |
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(–)-Scabronine G
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"Total Synthesis of (-)-Scabronine G, an Inducer of Neurotrophic Factor Production"
Stephen P. Waters, Yuan Tian, Yue-Ming Li, and Samuel J. Danishefsky
J. Am. Chem. Soc.; 2005; 127(39) pp 13514 - 13515. DOI Link
Presented by Ryan McFadden.
16 Sep 2005 |
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Minfiensine
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"Sequential Catalytic Asymmetric Heck-Iminium Ion Cyclization: Enantioselective Total Synthesis of the Strychnos Alkaloid Minfiensine"
Amy B. Dounay,, Larry E. Overman, and Aaron D. Wrobleski
J. Am. Chem. Soc.; 2005; 127(29) pp 10186 - 10187. DOI Link
Presented by Dan Caspi.
15 Jul 2005 |
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6-Deoxytetracycline Antibiotics
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"A Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics"
Mark G. Charest, Christian D. Lerner, Jason D. Brubaker, Dionicio R. Siegel, Andrew G. Myers
Science; 2005; 308(5720) pp 395 - 398. DOI Link
Presented by Jenny Roizen.
10 Jun 2005 |
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Mycalamide A
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"Total Synthesis of Mycalamide A"
Jeong-Hun Sohn, Nobuaki Waizumi, H. Marlon Zhong, and Viresh H. Rawal
J. Am. Chem. Soc.; 2005; 127(20) pp 7290 - 7291. DOI Link
Presented by Mike Meyer.
20 May 2005 |
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Stephacidin B
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"Enantioselective Synthesis of Stephacidin B"
Seth B. Herzon and Andrew G. Myers
J. Am. Chem. Soc.; 2005; 127(15) pp 5342 - 5344. DOI Link
Presented by Carolyn Woodroofe.
15 Apr 2005 |
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Isodomoic Acid C
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"The Synthesis of (-)-Isodomoic Acid C"
Jonathan Clayden, Faye E. Knowles, and Ian R. Baldwin
J. Am. Chem. Soc.; 2005; 127(8) pp 2412 - 2413. DOI Link
Presented by Tim Funk.
11 Mar 2005 |
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Kendomycin
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"Total Synthesis of Kendomycin: A Macro-C-Glycosidation Approach"
Yu Yuan, Hongbin Men, and Chulbom Lee
J. Am. Chem. Soc.; 2004; 126(45) pp 14720 - 14721. DOI Link
Presented by Ernie Cruz.
04 Feb 2005 |
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Ingenol
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"Total Synthesis of Ingenol"
Andrew Nickel, Toru Maruyama, Haifeng Tang, Prescott D. Murphy, Blake Greene, Naeem Yusuff, and John L. Wood
J. Am. Chem. Soc.; 2004; 126(50) pp 16300 - 16301. DOI Link
Presented by Mike Krout.
07 Jan 2005 |
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(±)-Jiadifenin
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"Total Synthesis of (±)-Jiadifenin, a Non-peptidyl Neurotrophic Modulator"
Young Shin Cho, David A. Carcache, Yuan Tian, Yue-Ming Li, and Samuel J. Danishefsky
J. Am. Chem. Soc.; 2004; 126(44) pp 14358 - 14359. DOI Link
Presented by Doug Behenna.
19 Nov 2004 |
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(+)-Yatakemycin
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"Total Synthesis, Structure Revision, and Absolute Configuration of (+)-Yatakemycin"
Tichenor, M. S.; Kastrinsky, D. B.; Boger, D. L.
J. Am. Chem. Soc. 2004; 126(27); 8396-8398. DOI Link
Presented by JT Mohr.
05 Nov 2004 |
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Biomimetic Approach to the Rocaglamides
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"A Biomimetic Approach to the Rocaglamides Employing Photogeneration of Oxidopyryliums Derived from 3-Hydroxyflavones"
Baudouin Gerard, Guilford Jones II, and John A. Porco, Jr.
J. Am. Chem. Soc.; 2004; 126(42) pp 13620 - 1362. DOI Link
Presented by Jenn Stockdill.
08 Oct 2004 |
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(-)-Siccanin
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"Biomimetic Enantioselective Total Synthesis of (-)-Siccanin via the Pd-Catalyzed Asymmetric Allylic Alkylation (AAA) and Sequential Radical Cyclizations"
Barry M. Trost, Hong C. Shen, and Jean-Philippe Surivet.
J. Am. Chem. Soc.; 2004; 126(39) pp 12565-12579. DOI Link
Presented by Tim Funk.
17 Sep 2004 |
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Norzoanthamine
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"Total Synthesis of Norzoanthamine"
Masaaki Miyashita,* Minoru Sasaki, Izumi Hattori, Mio Sakai, Keiji Tanino.
Science, Vol 305, Issue 5683, 495-499, 23 July 2004. DOI Link
Presented by Mike Krout.
03 Sep 2004 |
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(-)-Strychnine
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"Total Synthesis of (-)-Strychnine"
Yosuke Kaburagi, Hidetoshi Tokuyama, and Tohru Fukuyama
J. Am. Chem. Soc. 2004; 126(33) pp 10246 -10247. DOI Link
Presented by Uttam Tambar.
06 Aug 2004 |
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(±)-13-Methoxy-15-oxozoapatlin
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"Total Synthesis of (±)-13-Methoxy-15-oxozoapatlin, a Rearranged Kaurane Diterpenoid"
Robert A. Britton, Edward Piers, and Brian O. Patrick
J. Org. Chem. 2004; 69(9) pp 3068 -3075. DOI Link
Presented by Mike Meyer.
16 Jul 2004 |
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(-)-Penitrem D
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"Total Synthesis of (-)-Penitrem D"
Amos B. Smith, III, Naoki Kanoh, Haruaki Ishiyama, and Richard A. Hartz
J. Am. Chem. Soc. 2000; 122(45) pp 11254 -11255. DOI Link
Presented by Ryan McFadden.
04 Jun 2004 |
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(-)-Mycalamide A
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"A Formal Synthesis of (-)-Mycalamide A"
Barry M. Trost, Hanbiao Yang, and Gary D. Probst
J. Am. Chem. Soc. 2004; 126(1) pp 48 -49. DOI Link
Presented by Dave Ebner.
02 Apr 2004 |
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(-)-Gilbertine
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"Enantioselective Synthesis of (-)-Gilbertine via a Cationic Cascade Cyclization"
Jan Jiricek and Siegfried Blechert
J. Am. Chem. Soc.; 2004; 126(11) pp 3534 - 3538. DOI Link
Presented by Tim Funk.
18 Mar 2004 |
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(+)-Phomactin A
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"Total Synthesis of (+)-Phomactin A Using a B-Alkyl Suzuki Macrocyclization"
Peter J. Mohr and Randall L. Halcomb
J. Am. Chem. Soc.; 2003; 125(7) pp 1712 - 1713. DOI Link
Presented by Ernie Cruz.
27 Feb 2004 |
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Deacetoxyalcyonin Acetate
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"Toward a General Route to the Eunicellin Diterpenes: The Asymmetric Total Synthesis of Deacetoxyalcyonin Acetate"
Gary A. Molander, David J. St. Jean, Jr., and Julia Haas
J. Am. Chem. Soc.2004; 126(6) pp 1642 -1643. DOI Link
Presented by Haiming Zhang.
13 Feb 2004 |
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(-)-Tetrodotoxin
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"A Stereoselective Synthesis of (-)-Tetrodotoxin"
Andrew Hinman and J. Du Bois
J. Am. Chem. Soc. 2003; 125(38) pp 11510 -11511. DOI Link
Presented by Jenn Stockdill.
30 Jan 2004 |
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(±)-Didehydrostemofoline (Asparagamine A) and (±)-Isodidehydrostemofoline
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"Total Synthesis of (±)-Didehydrostemofoline (Asparagamine A) and (±)-Isodidehydrostemofoline"
Markus Bruggemann, Andrew I. McDonald, Larry E. Overman, Mark D. Rosen, Lothar Schwink, and Jeremy P. Scott
J. Am. Chem. Soc. 2003; 125(50) pp 15284 -15285. DOI Link
Presented by Neil Garg.
16 Jan 2004 |
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Aspidophytine
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"Enantioselective Total Synthesis of Aspidophytine"
Shinjiro Sumi, Koji Matsumoto, Hidetoshi Tokuyama, and Tohru Fukuyama
Org. Lett. 2003; 5(11) pp 1891 -1893. DOI Link
Presented by JT Mohr.
14 Nov 2003 |
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Elisapterosin B
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"A General Strategy to Elisabethane Diterpenes: Stereocontrolled Synthesis of Elisapterosin B via Oxidative Cyclization of an Elisabethin Precursor"
Nobuaki Waizumi, Ana R. Stankovic, and Viresh H. Rawal
J. Am. Chem. Soc.; 2003; 125(43) pp 13022 - 13023. DOI Link
Presented by Yeeman Ramtohul.
31 Oct 2003 |
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(-)-Terpestacin
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"Synthesis of (-)-Terpestacin via Catalytic, Stereoselective Fragment Coupling: Siccanol Is Terpestacin, Not 11-epi-Terpestacin"
Johann Chan and Timothy F. Jamison
J. Am. Chem. Soc. 2003; 125(38) pp 11514 -11515. DOI Link
Presented by Ryan Zeidan.
17 Oct 2003 |
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1-O-Methyllateriflorone
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"Total Synthesis of 1-O-Methyllateriflorone"
K. C. Nicolaou, Pradip K. Sasmal, Hao Xu, Kenji Namoto, and Andreas Ritzén
Angew. Chem. Int. Ed. 2003; 42(35) pp 4225 -4229. DOI Link
Presented by Dave Ebner.
03 Oct 2003 |
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(+)-Migrastatin
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"The Total Synthesis of (+)-Migrastatin"
Christoph Gaul, Jon T. Njardarson, and Samuel J. Danishefsky
J. Am. Chem. Soc. 2003; 125(20) pp 6042 -6043. DOI Link
Presented by Dan Caspi.
19 Sep 2003 |
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Merrilactone A
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"Total Synthesis of Merrilactone A"
Masayuki Inoue, Takaaki Sato, and Masahiro Hirama
J. Am. Chem. Soc. 2003; 125(36) pp 10772 -10773. DOI Link
Presented by Uttam Tambar.
05 Sep 2003 |
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Nakadomarin A
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"The First Total Synthesis of Nakadomarin A"
Toshiaki Nagata, Masako Nakagawa, and Atsushi Nishida
J. Am. Chem. Soc.; 2003; 125(25) pp 7484 - 7485. DOI Link
Presented by Ryan McFadden.
22 Aug 2003 |
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(±)-Pinnatal and (±)-Sterekunthal A
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"Biomimetic Synthesis of (±)-Pinnatal and (±)-Sterekunthal A"
Jeremiah P. Malerich and Dirk Trauner
J. Am. Chem. Soc.; 2003; 125(32); 9554-9555. DOI Link
Presented by Doug Behenna.
08 Aug 2003 |
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Cycloproparadicicol
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"A Concise Route to Benzofused Macrolactones via Ynolides: Cycloproparadicicol"
Zhi-Qiang Yang and Samuel J. Danishefsky
J. Am. Chem. Soc. 2003; 125(32) pp 9602 -9603. DOI Link
Presented by [unknown].
25 Jul 2003 |
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Cephalotaxine
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"A Novel and Efficient Total Synthesis of Cephalotaxine"
Wei-Dong Z. Li and Yong-Qiang Wang
Org. Lett.; 2003; 5(16) pp 2931 - 2934. DOI Link
Presented by Yeeman Ramtohul.
11 Jul 2003 |
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(-)-Ephedradine A (Orantine)
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"Stereocontrolled Total Synthesis of (-)-Ephedradine A (Orantine)"
Wataru Kurosawa, Toshiyuki Kan, and Tohru Fukuyama
J. Am. Chem. Soc. 2003; 125(27) pp 8112 -8113. DOI Link
Presented by Dave Ebner.
27 Jun 2003 |
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Briarellins E and F
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"Enantioselective Total Synthesis of Briarellins E and F: The First Total Syntheses of Briarellin Diterpenes"
Olivier Corminboeuf, Larry E. Overman, and Lewis D. Pennington
J. Am. Chem. Soc.; 2003; 125(22) pp 6650 - 6652. DOI Link
Presented by [unknown].
23 May 2003 |
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Oximidine II
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"Total Synthesis of the Salicylate Enamide Macrolide Oximidine II"
Xiang Wang and John A. Porco, Jr.
J. Am. Chem. Soc. 2003; 125(20) pp 6040 -6041. DOI Link
Presented by John Zepernick.
07 May 2003 |
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Okaramine N
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"Short, Enantioselective Total Synthesis of Okaramine N"
Phil S. Baran, Carlos A. Guerrero, and E. J. Corey
J. Am. Chem. Soc. 2003; 125(19) pp 5628 -5629. DOI Link
Presented by Dan Caspi.
25 Apr 2003 |
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(-)-Methylomuralide
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"A Short, Stereocontrolled, and Practical Synthesis of (-)-Methylomuralide, a Potent Inhibitor of Proteasome Function"
P. Saravanan and E. J. Corey
J. Org. Chem. 2003; 68(7) pp 2760 -2764. DOI Link
Presented by [unknown].
28 Mar 2003 |
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Quinolizidine Alkaloid (-)-217A
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"Highly Enantioenriched Tetrahydropyridines from Chiral Organosilanes: Application to the Synthesis of Quinolizidine Alkaloid (-)-217A"
Hongbing Huang, Thomas F. Spande, and James S. Panek
J. Am. Chem. Soc. 2003; 125(3) pp 626 -627. DOI Link
Presented by Uttam Tambar.
16 Jan 2003 |
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